I have no qualms with doing a rear mount as long as the vehicle has plenty of room for everything underneath it. A trailblazer at first glance looks like a good one for it, that resonator area would make a great "tucked up in" turbo area.... but in any case with a rear mount, proper piping sizes, a good proper sized intercooler, and a dedicated oiling system are a must to make them worth the time. If you size everything correctly and get some good tuning you can make them pretty efficient really.
As far as I6 vs. V8 360 platform's go any turbo would be build/ fab your own, so if you got the V8 go with a super/ procharger and keep the hassle to a minimum.
Us I6 guys will settle for homemade turbo setups.