I agree with the others - it looks off-center, more like where the t-stat is. Mine did leak from there, but it was b/c I had replaced the pump (& t-stat), tightened the t-stat housing exactly to spec, and then towing caused the bolts to loosen / leak. I fixed that with an extra couple ft/lb, along with some blue locker.
IIRC, when I tracked down that t-stat leak, the fluid wasn't 'directly' underneath, which also makes it hard to figure out, without seeing it directly.
It's hard to see in that area. I remember having to remove my airbox in order to actually 'see' the leak. One of those 'mirrors on a stick' helps, but it's still hard.
Depending on your mileage, I'd say go ahead and R&R the pump / t-stat. The pump tends to go south between 80-120K mi. If you're going for one, may as well do both. Good opportunity to convert the fan clutch, too, if you've had to replace one of those.
On the t-stat - if you have the 'old' housing, you have to use the 'old' thermostat. They're not interchangeable (although you can swap housings / t-stats, if you want the newer one). I have a Gates WP & a Stant t-stat; others say ACDelco is the way to go on these.
To bleed the air from the system after you've got everything back together, undo the throttle body hose on your right side (driver's side) as you fill the reservoir. Long needlenose helps here, as the clamp's not easy to get to (nothing is, with the 5.3 in this truck)