Here's my input:
I work on a fleet of about 17 Chevy Express 15 passenger vans. They all have a 6.0 (same manifold design). They all break on the front and rear of the head on both sides. Several of the vans have one of these installed and they work great.
There is a catch, though. This summer, one of the vans that had this part installed, had an exhaust manifold gasket start to leak. I thought, "no big deal, I'll just pull it, extract the broken bolts, install a new gasket, and be good to go". It all went great, I pulled out three broken bolts and started bolting the new manifold on. The bolt holes on the manifold wouldn't line up because the manifold was warped so bad.
I think that the manifold warped because it didn't have a bolt in the end holes to hold it in place. When you use one of these clamps, I think that just having a bolt pressing down on the manifold allows it to move too much as it heats and cools. I could be wrong though.
I think that the sooner you hear a leak and stick one of these clamps on, the better. That way you don't risk blowing out the gasket. I do have other vans that have had these installed for years and so far, no problems besides the one.